A microdosing schedule tells you which days you take a capsule and which days you don't. The classic one is 1 day on, 2 days off: 10 doses in four weeks. Here's a four-week calendar for each common protocol, why the days off matter, and how to pick the one that fits your week.
A microdosing schedule is a repeating pattern of dose days and off days, and the off days are there to keep tolerance down. Psilocybin tolerance builds fast. The day after a dose, you'd need about 2× the amount to feel the same thing. By day 3 that's about 1.5×, by day 7 about 1.15×, and it's mostly back to baseline by day 14.
So dosing every day isn't a stronger version of microdosing. Each capsule just does less than the one before. Spacing your doses keeps a 150 mg capsule working like 150 mg. The tolerance calculator shows what the number of days since your last dose means for the next one.
The research supports spacing doses but doesn't pick a winning schedule. A qualitative study of microdosing practices found that once every three days was the regimen people reported most. An observational study of 953 psilocybin microdosers noted that surveys generally land on 3–5 times per week at 0.1–0.3 g of dried mushroom. Nobody has shown that one schedule beats the others.
The Fadiman protocol is one dose, then two days with nothing, then the cycle starts again. That's a capsule every third day, or 10 doses in 28 days. It's the classic approach and the one we suggest for a first month.
The usual explanation is that a dose carries over into the next day, and the third day gives you a clean baseline. A 2025 University of British Columbia Okanagan diary study questioned that. Participants reported feeling more connected, creative and focused on dose days, but those effects didn't appear to persist on the days they didn't dose. Either way, two off days keep tolerance low and give you something to compare against.
The Stamets stack is four dose days in a row, then three days off, every week. That's 16 doses in four weeks, about 1.6 times what Fadiman uses. Its main advantage is that it's easy to remember: Monday to Thursday on, Friday to Sunday off.
The cost is tolerance. By day 4 of a run you've dosed three days in a row, so the fourth capsule usually lands softer than the first. Three off days bring you partway back to baseline, not all the way. The original version also pairs each dose with other supplements. We don't sell those, so this page only covers the timing.
Stamets uses 16 capsules in four weeks, against 10 on Fadiman. If you start on Stamets, start at 150 mg. Softer days 3 and 4 make it tempting to go up a strength, and that's usually the wrong fix.
Every-other-day dosing is one day on, one day off, which comes to 14 doses in four weeks. It sits between Fadiman and Stamets. Each dose comes after a single off day, when you'd still need about 2× to feel the same thing, so the same capsule may feel a little weaker than it would on Fadiman.
Intuitive microdosing means you dose when it suits your week and still keep regular rest days. It works for people who've done at least four weeks on a fixed schedule and know what a dose day feels like for them. For a beginner it usually turns into guesswork: there's no baseline to compare against, and it's easy to slide into dosing more often than you meant to.
Here's what 28 days look like on each schedule, starting on a Monday. Fadiman doesn't line up with a 7-day week, so your dose days move forward one weekday each cycle.
Dose days over 28 days (week 1 starts Monday)
| Week | Fadiman (1 on, 2 off) | Stamets (4 on, 3 off) | Every other day |
|---|---|---|---|
| Week 1 | Mon, Thu, Sun | Mon, Tue, Wed, Thu | Mon, Wed, Fri, Sun |
| Week 2 | Wed, Sat | Mon, Tue, Wed, Thu | Tue, Thu, Sat |
| Week 3 | Tue, Fri | Mon, Tue, Wed, Thu | Mon, Wed, Fri, Sun |
| Week 4 | Mon, Thu, Sun | Mon, Tue, Wed, Thu | Tue, Thu, Sat |
| Doses in 28 days | 10 | 16 | 14 |
| Capsule pack that covers it | 10 capsules | 20 capsules (4 left over) | 20 capsules (6 left over) |
Starting on another weekday? Shift the whole table. Whatever day you start, make your first dose a quiet day when you don't have to drive, present or make big decisions. You'll see how it affects you before you take one on a busy day.
If it's your first month, pick Fadiman. It uses the fewest capsules, keeps tolerance lowest and gives you the most off days to compare against. After four weeks you'll have 10 dose days to look back on, which is enough to tell whether you want more or less.
Which schedule fits which situation
| If this sounds like you | Try | Why |
|---|---|---|
| First month, never microdosed | Fadiman | Lowest tolerance, most baseline days, 10 capsules |
| You want dose days on the same weekdays every week | Stamets | Mon–Thu every week is easy to remember |
| Your sleep is easily thrown off | Fadiman, dosing in the morning | Fewer dose days and more recovery between them |
| After a full month, Fadiman doses felt too far apart | Every other day | 14 dose days without four in a row |
| You've done four weeks or more and know your dose | Intuitive, with rest days | Flexibility once you know your own response |
We suggest dosing in the morning, because people commonly report that a capsule taken late in the day gets in the way of sleep. Keep a short daily note for the 28 days: sleep, mood, focus, anything that felt off. Write it on off days too, or you'll have nothing to compare against.
Switch schedules only after a full four-week run, and change one thing at a time. If you change the schedule and the strength in the same week, you won't know which one made the difference.
If you see visual changes, feel wired or can't focus, the dose is too high for a microdose. Skip the next scheduled dose, then come back at a lower strength.
A common approach is to run a schedule for 4 to 8 weeks, then stop for at least 2 weeks. That lines up with tolerance returning to baseline around day 14, so the next round starts fresh.
More anxiety, poor sleep, headaches or low mood are reasons to stop, not to push through. Text or call us at (971) 370-8474, daily 10 am–10 pm PT, and we'll talk it through.
Travel, illness or a stressful week are good reasons to pause. When you come back, start again at day 1 of your schedule.
SSRIs and other antidepressants can blunt the effects. MAOIs and lithium can be dangerous in combination with psilocybin. If you take prescription medication, talk to a healthcare professional first. Don't microdose if you or a close family member has a history of schizophrenia, psychosis or bipolar disorder, or while you're pregnant or breastfeeding. If you're in crisis, call the SAMHSA National Helpline at 1-800-662-4357 (free, confidential, 24/7) or the 988 Suicide & Crisis Lifeline. Nothing on this page is medical advice.
For your first month, take 150 mg capsules whichever schedule you pick. A typical microdose is 100–300 mg of dried mushroom. Our capsules are filled to an exact 150, 350 or 600 mg of dried mushroom material (the weight of mushroom, not the psilocybin content), so there's nothing to weigh (measuring dried mushrooms by hand is harder than it sounds). The dosage calculator shows where your body weight and experience put you.
What each schedule costs in capsules (prices from /order)
| Schedule | Capsules needed | 150 mg | 350 mg |
|---|---|---|---|
| Fadiman, 4 weeks | 10 | 10 caps $100 | 10 caps $125 |
| Every other day, 4 weeks | 14 | 20 caps $160 | 20 caps $200 |
| Stamets, 4 weeks | 16 | 20 caps $160 | 20 caps $200 |
| Fadiman, 16 weeks | 40 | 40 caps $280 | 40 caps $350 |
350 mg is above the typical 100–300 mg microdose range. It suits people who've done a full month at 150 mg without noticing much, or whose body weight puts them higher on the chart, so check the calculator before you step up. 600 mg isn't a first-month microdose for most people. Strain matters too: Golden Teacher is the potency the dosing chart assumes, while Albino Penis Envy and Albino Bluey Vuitton are stronger by weight. Start those at the bottom of any range, or below it.
You'll find the 150 mg and 350 mg capsules on the order page in all three strains. Bulk tiers are 20% off at 20 capsules and 30% off at 40. Every order comes with free dosage guidance, so if you can't decide on a schedule, text us and ask.
Finding that once every three days was the most-reported microdosing regimen
tandfonline.comSurvey convergence on 3–5 doses per week at 0.1–0.3 g dried mushroom; study size of 953 psilocybin microdosers
ncbi.nlm.nih.govDiary-study finding that reported effects showed up on dose days but didn't appear to persist on non-dosing days
news.ok.ubc.caA first month on Fadiman takes one 10-capsule pack of 150 mg, $100. Every batch is lab-tested, orders ship in plain, unmarked packaging, and every order comes with free dosage guidance from a real person. Text or call (971) 370-8474, daily 10 am to 10 pm PT.
